Originally Posted by Sharkie&Sparx Mum
...Is it likely he will suffer from arthritis, is that common as he's suffered a broken limb?
I think it's "common knowlege/experience" in humans that, when one has suffered certain types of injury in early life (broken bones, severe repetitive injury e.g. sports injuries) it can be expected that "arthritic-type pain" will be experienced later on down the road, and, often, earlier than the"age-related" arthritic pain of later years.
Similarly, the same holds true for cats. "Ordinary" arthritis, known as Degenerative Joint Disease is extremely common in cats
Arthritis is a broad term used to describe inflammation of a joint. We often use this term when referring to degenerative joint disease associated with wear and tear. It is not limited to ageing pets, but can also develop in young pets following injury to a joint
. Arthritis in Dogs and Cats | Darwin Veterinary Centre
Joint trauma can also lead to secondary DJD, including any fracture that involves a joint surface. Joint fractures need to be reduced and stabilized precisely to prevent the occurrence of DJD. Any incongruity during healing will result in degeneration. Hip and elbow fractures occur fairly frequently. A traumatic dislocation of a joint can produce severe DJD if not treated appropriately. Cats are susceptible to ligament injuries, in particular the cranial cruciate ligament (CCL) of the knee, which is the most common injury to the canine stifle. Cranial cruciate rupture causes variable amounts of DJD. Degenerative Arthritis in Cats - Page 2
Now, for the Metacam.
Metacam for oral dosing is licensed for use in cats in the UK. It is not so in the USA, where only a one-time injection is approved for felines. It was only last year that oral administration was approved in Canada.
Metacam is known to cause kidney damage. It destroysline kidney cells. That was proven in the manufacturer's own initial laboratory studies. Cats are one of the few mamals that cannot metabolize non-steroidal antiinflammatory drugs...so, the drug is absorbed in the blood where it travels through the kidneys - and it's there that the damage is done. The greater amount of the drug, the greater the damage. Now, those kidneys have millions of filtering cells, some of them working and some in reserve. When cells die off, others step up and take over. However, these cells cannot regenerate, so over time, there will be insufficient of these "nephrons" to do the filtration - that's when the symptoms of kidney failure begin to appear.
So, with Metacam, it really isn't a question of whether/not it's safe...the question really is "How much kidney tissue is to be sacrificed to eliminate pain?"
For me, any damage is too much. And, when there are other, safer pain relievers available? I say, hands down, none of that for my cats.
The manufacturer of Metacam has gone 'all-out' to market this drug. They've paid for numerous studies which (surprise, surprise) have concluded that the drug is "safe" for cats. There's even a study that purports that Metacam may even HELP kidney-failure kitties! The marketing of this drug is relentless - have a read here (where they're 'partnering' with well-known organizations)
As part of the brief to promote Metacam, the agency has been given responsibility for launching a campaign aimed at educating owners about the signs of chronic and post-operative pain in their cats.
The Spot the Signs campaign will see Boehringer Ingelheim join forces with charity FAB Cats to raise awareness
of the common signs of cat pain among owners, while promoting the importance among veterinary professionals of discussing pain relief with their clients. Pharmaceutical giant Boehringer Ingelheim hands Pegasus animal drug brief | PR & public relations news | PRWeek
The result: in the UK, it's now being given out like candy - as evidenced in posts on UK pet forums.
So far as the dosage you've been prescribed is concerned, because you're using the approved syringe (automatically doses by cat's weight), I can only presume that the amount is "standrd/approved" as per the NOAH guidelines. HOWEVER, those guidelines also specify for a maximum of four days
- you can read that right here:
IF a cat has been on this drug regimen for two weeks, I would be very concerned. I would not be waiting until Thursday for this - I'd seek an alternative option as soon as I could.
The easiest pain control is available through the "pain patch" - an adhesive strip which transmits the pain med through the skin and lasts about four days. Next best in my book is Burpinex (buprenorphine) which is dropped into the mouth and simply absorbed by oral tissue. Both are very effective pain control in cats.
This repeated oral dosing of Metacam was "outlawed" by the US FDA - here's the notice about that: FDA Announces Addition of Boxed Warning to METACAM® (meloxicam) Labels