I'm not sure, but we have had similar problems with Beeper. We just don't let her and the other cats together at all. Hate to sound callous, but since it's not something we're going to be dealing with for much more than a few years, it's not worth the stress for her and us. She's an old girl, we'll let her enjoy her retirement in peace.
Anyway, we have had incidences of seemingly unprovoked hissing. I think a lot of it is redirected aggression. She sees the cats/smells the cats/smells them on us/associates them with us/etc...whatever it is, it can often trigger spats of hissing directed at us, and we've just learned to back off until she calms down. We don't want to turn redirected aggression into direct aggression by forcing interaction.
Another problem - for her, at least - is arthritis. Often when we're picking her up, or petting her in a certain area, she'll hiss and spit. Poor girl's likely in pain and taking it out on anyone near her. The new supplements will take a few weeks to fully kick in, so we're riding her crankiness out 'till then. Is there any sort of physical pain Tigger could be in? (I've forgotten how old he is)
It could be that the other cats are inadvertantly hurting him when they play, and he's lashing out in response. Also, the more negative interactions they have, the more their future interactions are soured. I'd do anything I could to stop fights before they happen.
Senility is often manifested as unprovoked aggression in dogs, it makes sense that cats could have the same problems. Whatever's going on in their little heads, it makes sense to them. Tigger knows why Tigger wants to see Kiley and Halifax's food. Tigger knows why and when the other cats are annoying him, and he responds appropriately. I don't know that there's a whole lot you can do to change their minds, so for us when Beeper gets cranky, we're just like, "Okaaaay, then," and back off.