Yes, we have left our cats for up to four days at a time with no one checking on them. More than that and we call the pet sitter.
Like Tim said, multiple water dishes are key in case one spills. I always put out at least one big container (a gallon or so) of water that won't evaporate completely. I don't fill the sink or leave toilet seats up -- don't want anyone to fall in!!
I also do a major
cat-proofing. I turn off the breakers to items that aren't needed or are a fire hazard, like the dryer and the stove. I shut our laundry, office, and all the bedroom and bathroom doors -- this makes for fewer rooms to worry about.
We try to leave everything as clean and clutter-free as possible -- not easy to do with our kids.
Lastly, I unplug everything
in the rooms where the cats will be. Granted, I have kittens who knock over lamps and chew things, so I tend to be extra careful. And, it's a small chore to ensure less worry.
We take short trips regularly and have never had a problem. I'm sure your kitties will be just fine!