Re: Please help!!! I don't know what to do.
Welcome, and I hope we can help you with your cat problem.
First, I think you've played Russian Roulette with your cats and managed to get lucky until this litter came along.
Most female cats will become rabidly protective over their litter, no matter how close of friends the cats were beforehand. It is an instinctual response and there is no way to know for certain what set her off *this* time, when she was fine the other times.
If I had to guess, I would say Sox either saw or smelled another cat and it triggered her protective instincts.
This is a common form of 'misdirected aggression' where a cat sees/smells/hears something that unsettles it and puts them on edge. Because they have no outlet to reach the source of what is bothering them, they can attack whatever is nearest...which can be pets they've been great friends with all their lives or even their people. A cat who does this isn't mean or crazy, its' instincts are demanding it behave in a certain manner and they are trying to comply and release the aggression and/or protective instincts their body is demanding be expended.
SEPERATE THEM. Sox and her litter should go into 'isolation' to protect Fonzy.
I've only had one cat (Shadow) kitten in my home in 2004, but I've raised numerous foster and orphaned kitten litters. They all stayed in my master bathroom and as they got older and would come to me when called, they were allowed into the master bedroom for exercise and more room to explore during the day. I brought Shadow into my home when she was hugely pregnant and she kittened 10 days later. At first she was very friendly with all of the housecats but as soon as her litter was born, she became a changed cat and I had to be *very* careful to never let her and the other cats mingle because of her protective instincts. After her litter was weaned and taken to the adoption center, she relaxed and was happy to meet the other housecats. She has turned into a great little cat (sleeping on the desk next to me right now) who gets along with all the other cats.
Finally, I am very sorry to just butt-in, but I feel I must urge you to please spay Sox. Every litter from a non-pedigree'd cat is contributing to the huge numbers of pet-overpopulation.
In addition, I would also like to urge you to stop letting Fonzy, a de-clawed cat whom you have admitted has no way to defend himself, outside unattended. The dangers are great for cats who *do* have the means to defend themselves. The dangers are far greater for a cat who *does not* have the means to defend himself.
Best of luck with Sox and Fonzy.