Sadie and Talon have lived together fairly peacefully for about 4 years. Sadie was never really crazy about Talon, but she tolerated her and everyone was happy! Recently, my husband and I came out of a 2 month separation, and reintroduced the cats. Now they are aggressive! Sadie won't leave the bedroom closet and we have to shut the bedroom door for hours before she will leave the closet to come out and use the litterbox and eat/drink. She hisses so much she is foaming at the mouth and in three days I can already see some weight loss. Talon is ruling the house, as she is the tougher cat (she was a stray we rescued). Sadie is my baby and I am most worried about her! Am I going to need to find a new home for Talon? I would really like to keep both my kitties, as they are both a part of my family. Will they get over this?

All advice is welcome!
Darci

Welcome, and I hope we can help you.
First, cats are *not* like dogs who can go away and return believeing everybody is their friend. Cats are much more territorial, though they can learn to live/exist together and tolerate each other. Removing a cat and returning a cat is not as simple as 'oh, it will be the same as it was before'. That almost *never* happens, unless the group of cats is *used* to cats coming/going for periods of time. Your cats have forgotten about each other and are each treating the other like an intruder.
You will need to start completely from scratch to repair this damage done. Please do some searches for "cat introductions" and/or 'reintroductions'. Go slowly, and you may find the pheromone diffuser "Fel-i-way" to be helpful, as it releases a smell that chemically signals 'calming thoughts' to the cats.
Best of luck,
heidi