I do alot of online shopping, just not at Ebay. I've done a few transactions on Ebay, but they were minor. I've only been screwed once. I received a cordless phone I wanted, but the wrong color. They sent black, and that's a awful choice IMO. I ordered white, so I sent it back telling them they messed up and never did receive my phone. I e-mailed and everything. The website went offline a month or so later. I was out almost 100 bucks, because it was a new phone with new technology, like 2.4 GHz.
Other than that, I always have good luck shopping online with reputable stores. I order computer parts online, medical books, and all kinds of stuff I can't get in town or would rather not shop for. It's safe in most cases, just do your homework on the place before buying.