It seems as if, for whatever reason, things got to be too much for your grandmother to handle. It must break her heart to see what has happened to her lovely home--even if she was responsible for allowing it to get cluttered. I don't know, of course. It would be lovely if the family pitched in and put in back the way it was, even if they had to hire some help. I think she would be overjoyed.
Of course you don't want to throw away anything she would consider important, but one room could be designated as the room for items not being used right now, and you could show her where to find what. A couple of closets could be fitted with organizers, shelves, etc., and many things could be stored there. I can't think of a nicer thing you could do. I think grandmother would weep for joy.
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A dog, I have always said, is prose; a cat is a poem. ~Jean Burden