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Hello all. Looking for help. My female cat and my male cat are litter mates. They have been together all of their lives. We adopted them when they were eight weeks old they are now four. Up until four days ago they got along great other than some rough and tumble play. Four days ago it turned really rough. My female cat has basically turned on my male cat without warning. Biting hissing growling. Some of the most crazy noises I have ever heard. She will pin him into a corner and not allow him to move. He defends himself but doesn’t know exactly what to do. This has been quite confusing to all involved. We haven’t changed anything. We have separated them for about 24 hours and then they were okay for another day only for it to happen a day later. We have multiple litter boxes and food bowls around the house. I do think that maybe it could be a territorial thing but I am not sure. We have an outdoor cat that does like to come around but I’m not sure if that’s the cause either. They used to get along so well. It’s heartbreaking to have to separate them and keep one locked up. Especially since they seem to miss one another. Anyone have any suggestions. We have bought some calming gummies and she is scheduled for a vet visit in February. Just looking for some sort of insight or even some reassurance that this is normal. I hate having them apart but I am so worried about them together.