I'm a pro at this. My Erik spent the first 6 years of his time with me, back when he was a barn cat, behaving entirely as if he were feral. Once he moved into the house, he quickly tamed down, but for 6 years I applied Frontline thusly. You will need a 1cc syringe--one w/ a tiny needle on it. It needs to be a removable needle, not a TB syringe w/ the needle permanently applied.
(1) Take Frontline ampule out of package. Do NOT break the top as you normally would to apply.
(2) Holding the ampule so that the liquid is pooling all in one corner, use the syringe w/ the needle to go in through the foil backing and suck out all the fluid. This takes a little practice. Get as much of it as you can.
(3) Cap the needle and remove it.
(4) Wash your hands so you don't smell of Frontline.
(5) Feed the cat something really good. Lean down, pet once or twice, then aim the syringe tip into the coat, get it down the skin and depress the plunger. Do this QUICKLY.
This works MUCH better than trying to apply w/ the ampule b/c it's much faster and cleaner--it all comes out at once from the syringe, instead of your having to repeatedly squeeze the ampule.
I recommend getting kitty in the habit of your petting him while he is eating. Do it for a few days before applying the Frontline--and then keep doing it afterwards. If 29 days a month all that happens is petting and only ONE day a month he gets Frontline, he won't get wary.