Good morning. I have 5 kitties, 4 of them rescue cats. My oldest kitty, Mollie, who is 13, has been peeing just outside the litter box for the last couple of months. She has been to the vet for ultraounds of her bladder, urine culture, basic blood work and everything came up with cystitis and some arthritis. The vet tried her on apresoline, which I stopped as she was so doped up it was awful and she was very very irritable. We have tried buprenex for 4 days now and her mood has improved tremendously but she is still peeing outside the litter box. I don't want to keep her on buprenex and was wondering if anyone else had any ideas. I was wondering about maybe her anal gland should be checked. I am running out of ideas. She doesn't like my other cats but has never had problems with them before.