Sure, since they're kittens, you can get them used to you opening their mouths and just poking around gently with the brush. They usually lose their kitten teeth and get their perm ones anywhere from 4-6 mths, so after that you can really start in on the brushing. Be very gentle, as their gums are more delicate than humans. I brush mine daily, using finger brushes and kittypaste. Good luck!